MK 733

《英文MSH詞典》MK 733
[入口詞] MK 733
[主題詞] Simvastatin
[藥動學] Hydroxymethylglutaryl-CoA Reductase Inhibitors
[英文釋義] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES),which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS,it increases breakdown of LDL-cholesterol (LIPOPROTEINS,LDL CHOLESTEROL).